Each Phenylpropanolamine (PPA) chewable tablet contains 50 mg of phenylpropanolamine hydrochloride. Besides aging, other possible causes of incontinence include: 1. veterinarian whether you can safely use this drug for your dog. Pupil dilation is performed during some portions of an eye examination. α-Adrenergic agonists such as phenylpropanolamine (PPA), ephedrine, pseudoephedrine, and phenylephrine act directly on smooth muscle receptors to increase urethral tone and maximal urethral closure pressure. It also comes in liquid in 3 or 6 mg/ml strengths. {R-3; 5} Absorption: Although no information is available on the absorption of diethylstilbestrol in dogs, it is believed to be well absorbed. Of this class of drugs, PPA is the most effective and results in fewer cardiovascular adverse effects. Phenylephrine is in a class of medications called nasal decongestants. While urinary incontinence isn't harmful in itself, if left untreated it can lead to skin conditions or, in some cases, to more serious kidney or bladder infections. PPA is indicated for the control of urinary incontinence caused by urethral sphincter incompetence in female dogs. Dogs: 0.1–0.3 mg/kg/day, PO, for 7–10 days, followed by 1 mg/dog/wk, Dogs: 1.5–2 mg/kg, PO, once to three times daily. PPA is indicated for the control of urinary incontinence caused by urethral sphincter incompetence in female dogs. Risk of cardiac arrhythmia is increased when PPA is administered concomitantly with halogenated gas anesthetic agents. DES is given as a daily loading dose for 7–10 days and then reduced to once weekly dosing, if possible, to avoid toxicity. Incontinence often occurs in middle aged or older spayed female dogs. Phenylpropanolamine is an α- and β-adrenergic agonist that stimulates smooth muscle contraction of the internal urethral sphincter, increasing urethral sphincter tone and closure of the bladder neck. Updated: 2021-01-29. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. In male dogs, testosterone injections are used to treat urinary incontinence but are generally less effective than estrogen therapy in female dogs. Select one or more newsletters to continue. Reduced urethral sphincter tone may result in urinary incontinence, a condition seen in primarily in ovariohysterectomized bitches but also in aged, obese bitches and occasionally in neutered male or intact dogs. Urinary incontinence in female spayed dogs should not be ignored. increased dog urethral sensitivity to alpha-adrenergic agonists, such as phenylephrine. It is orally bioavailable and reaches peak plasma concentrations in 1 hr in dogs; it has an elimination half-life of 24 hr because of enterohepatic recirculation. Is your dog already exhibiting any of the above symptoms? Phenylephrine Phenylephrine is less of a risk due to low oral bioavailability. The most common types of decongestants are pseudoephedrine and phenylephrine. Phenylephrine may also be used with other drugs such as atropine , to … NADA# 141-324 The effects of stilboestrol and progesterone on pressure responses of the urethra to the alpha-adrenergic agonist, phenylephrine, were investigated in normal and incontinent ovariectomised dogs. Show more Incontinence – When dogs get older, they sometimes lose control over their urethral sphincter which is the muscle that holds urine in the bladder – this leads to incontinence. Sudafed Pseudoephedrine is a decongestant found in many cold remedies, but acts like a stimulant in dogs, who can experience elevated heart rates and seizures. Urethral sphincter hypotonus causes canine urinary incontinence as a result of weakened muscles of the urethral sphincter. Keep container tightly closed. PPA should not be administered with other sympathomimetic drugs, tricyclic antidepressants, or within two weeks of administering monoamine oxidase inhibitors, due to the risk of acute hypertension. Last full review/revision Feb 2015 | Content last modified Feb 2015, © 2020 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA), © 2021 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA, Noninfectious Diseases of the Urinary System in Dogs, Noninfectious Diseases of the Urinary System of Cats, Disorders of Micturition in Small Animals. PPA should be avoided or used with caution in dogs with glaucoma, cardiovascular disease, hypertension, renal insufficiency, and diabetes mellitus. Of the ninety-seven dogs with dose reductions below 2 mg per day, all dogs receiving 1 mg of INCURIN™ Tablets once daily (n = 41), 1 mg every other day (n = 5), or 0.5 mg every other day (n = 24) had either reduced or no incontinence compared to Day 0. 3 mg/kg body weight per day PO, administered as 1.5 mg/kg PO BID or 1.0 mg/kg PO TID. The Veterinary Manual was first published in 1955 as a service to the community. This site complies with the HONcode standard for trustworthy health information: verify here. Urinary Incontinence. Dog incontinence is a health condition that occurs more frequently in older dogs, even though there are other factors that may lead to involuntary urination. Because it is inexpensive and infrequently administered, it is the first choice to treat urinary incontinence in female dogs. It may take several days for the full benefit of the drug to take place. Ephedrine, pseudoephedrine, or phenylephrine may be tried but are less efficacious than PPA. We do not control or have responsibility for the content of any third-party site.   See your vet and they may be able to prescribe a medication … So, this health hazard is not unique to Sudafed. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. It is still available for veterinary use in dogs, however, as a treatment for urinary incontinence. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Monitor Your Buddy Manufactured by Neogen Corporation, Lexington, KY 40511, Copyright © 2021 Animalytix LLC. The dose and frequency needed for each animal tend to vary widely and may need to be increased over time to maintain continence (Table 1). In veterinary medicine, it is used to control urinary incontinence in dogs. , DVM, MSc, DACVIM, DACVCP, Veterinary Clinical Pharmacology, Western College of Veterinary Medicine, University of Saskatchewan. Compared with phenylephrine, the experimental agent exhibited a potency factor 2.73 times greater with regard to the contraction of the urethra and with a duration longer by a … We cannot confirm the completeness, accuracy and currency of the content. Although often more clinically effective than DES, their action is short lived, usually requiring dosing bid-tid. Urinary incontinence is a condition that makes dogs pass urine uncontrollably and it's the most common sign of bladder issues in dogs. Kidney Failure – Ingestion of certain toxic substances like antifreeze can lead to kidney failure in … It is most common in large breed, spayed female dogs (11%–20% incidence) but may be seen in intact females, male dogs, and cats. Creed *. Phenylpropanolamine Chewable Tablets (50 mg). Store at controlled room temperature. Complications may mean a dose was too strong or they may simply be rejecting it. Effect of hormones on urethral sensitivity to phenylephrine in normal and incontinent dogs. Ephedrine, pseudoephedrine, or phenylephrine may be tried but are less efficacious than PPA. Phenylpropanolamine (PPA) (Proin, prnpharmacal.com) is the most widely used α-agonist for the treatment of UI. DES continues to be available to patients through compounding pharmacies ; however, estriol has since received FDA approval and represents a new way to use estrogens for sphincter incontinence in female dogs. Hematopoietic toxicity is rarely seen in cats. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Phenylpropanolamine Chewable Tablets (50 mg) Indications. Protect tablets from light. Pseudoephedrine is a sympathomimetic used as an oral decongestant in humans. For respiratory symptoms, the dosage in dogs is 0.1 to 0.2 mg per pound (0.2 to 0.4 mg/kg) or 15 to 60 mg per dog by mouth every 8 to 12 hours. Reading of labels is a must! Keep this and all medications out of the reach of children. Other adverse effects seen in dogs include alopecia, cystic ovaries, cystic endometrial hyperplasia, pyometra, prolonged estrus, and infertility. If your dog is hairy, clip around the dog's private area to assist with cleanliness. In dogs it has been suggested for controlling urinary incontinence. Possible side effects include restlessness, CNS excitation, irritability, tachycardia, hypertension, and anorexia. Some dogs show signs at therapeutic doses of pseudoephedrine while moderate to severe signs can occur at 5-6 mg/kg and fatalities can be seen at 10-12 mg/kg. Phenylpropanolamine (PPA) is a drug of the phenethylamine family used as a decongestant and also as an appetite suppressant. We comply with the HONcode standard for trustworthy health information -, Phenylpropanolamine Chewable Tablets (50 mg) Indications, Warnings and cautions for Phenylpropanolamine Chewable Tablets (50 mg), Direction and dosage information for Phenylpropanolamine Chewable Tablets (50 mg). If you think your dog got into your medicine cabinet and ate some Sudafed, it’s highly recommended to take them to a vet immediately. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It is usually caused by hormonal deficiencies that result in a loss of control of the urethral sphincter (the muscle that prevents urine from leaking out of the bladder), but structural or neurological problems can also be involved. You'll often notice it as she gets up from laying down. These drugs are commonly found in cold, flu and allergy medications (especially those with a “ … The legacy of this great resource continues in the online and mobile app versions today. In male dogs, testosterone injections are used to treat urinary incontinence but are generally less effective than estrogen therapy in female dogs. Effect of hormones on urethral sensitivity to phenylephrine in normal and incontinent dogs. Phenylephrine and entry 1, 30 and 10μg/kg, respectively, were introduced into the vena femoralis through a polyethylene cannula. Decongestants work by constricting (or tightening) the blood vessels in the nose (and the rest of the body). Despite the poor solubility of diethylstilbestrol, its physical characteristics suggest permeability in the Urinary incontinence is most commonly caused by urethral sphincter incompetence. The urethra is the tube that runs between the bladder and the outside of the body. Human Warnings: Not for human use. Adverse effects of α-adrenergic drugs include excitability, restlessness, hypertension, and anorexia. Adverse effects of α-adrenergic drugs include excitability, restlessness, hypertension, and anorexia. The originating document has been archived. Every effort has been made to ensure the accuracy of the Phenylpropanolamine Chewable Tablets (50 mg) information published above. Urinary incontinence most commonly affects spayed, female dogs but can develop in any individual. Urinary Incontinence. Previously available in over-the-counter cold medications and appetite suppressants, it was withdrawn from the human market because of toxicity associated with overuse as a diet aid. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Diethylstilbestrol (DES) is a nonsteroidal estrogen derivative that closely resembles the natural estrogen, estradiol. If so, it’s even more urgent to head to a clinic! Phenylephrine is in most decongestants, including Sudafed, and dogs don’t handle it well. This FDA-approved drug is commercially available in doses designed for use in dogs. When used once weekly in spayed female dogs, adverse effects from DES are rare. The trusted provider of veterinary information since 1955, Systemic Pharmacotherapeutics of the Urinary System, Overview of Systemic Pharmacotherapeutics of the Urinary System, Cystine-binding Agents in Urinary Disease, Systemic Pharmacotherapeutics of the Cardiovascular System. Please confirm that you are a health care professional. Keep the dog's private areas clean. (phenylpropanolamine hydrochloride) For the control of canine urinary incontinence due to urethral sphincter hypotonus. Available for Android and iOS devices. Estrogens sensitize the urethral sphincter to α-adrenergic stimulation; therefore, DES therapy is synergistic with α-adrenergic drugs. Also, while your dog is having issues with incontinence, wash the tail and back legs twice a day with mild soap and warm water. It works by reducing swelling of the nasal passages. Keep out of the reach of children. Merck & Co., Inc., Kenilworth, NJ, USA (known as MSD outside of the US and Canada) is a global healthcare leader working to help the world be well. PPA 50 mg tablets are available in 60 count and 180 count bottles. Urinary bladder disorders can cause urine leakage if urine is not stored properly or if urine retention causes overflow. One common problem with older female dogs, in particular, is leaking urine. Phenylephrine is the active ingredient in many decongestants. There is limited information on the toxic dose of ephedrine Ephedrine. Please refer to the following dosage charts: * Veterinarian may compound the drug for patients weighing 7 lb and under. Adverse reactions related to administration of PPA may include restlessness, excitation, irritability, tachycardia, hypertension, vomiting, and anorexia. Soon, the sphincter incontinence that is common in spayed female dogs was also being treated effectively with estrogen in the form of diethylstilbestrol (DES). Creed KE. Currently, there are no approved drugs to treat incontinence in animals, and most of the human products traditionally used have been removed from the market because of toxicity concerns. In cats, it is dosed at 0.5 mg per pound (1 mg/kg) orally every 8 hours. Internationally, an item on the agenda of the 2000 Commission on Narcotic Drugs session called for including the stereoisomer norephedrine in Table I of United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances . It is available in 15 mg, 30 mg, 60 mg, 120 mg (12-hour extended release) or 240 mg (24-hour extended release) via tablet. Author links open overlay panel K.E. And play it safe by going to a vet whenever your dog may have been given a risky drug. Dogs and cats with left-side congestive heart failure (CHF) can develop respiratory distress due to pulmonary edema. For urethral tone problems in dogs, Pseudoephedrine is dosed at 0.75 mg per pound (1.5 mg/kg) orally every 8 to 12 hours. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. Not for human use. The most common cause of urinary incontinence is weak urethral musculature. Some estrogen compounds and α-adrenergic drugs may still be available to veterinarians through compounding pharmacies (see Table: Drugs Used to Treat Urinary Incontinence). Dosage & Administration: 3 mg/kg body weight per day PO, administered as 1.5 mg/kg PO BID or 1.0 mg/kg PO TID. Alpha-adrenergic agonists are a class of sympathomimetic agents that selectively stimulates alpha adrenergic receptors.The alpha-adrenergic receptor has two subclasses α 1 and α 2.Alpha 2 receptors are associated with sympatholytic properties. Phenylephrine HCl, commonly known as Ak-Dilate® or Ak-Nephrin®, is an agent used to dilate the pupil in dogs and cats. Women who are of child-bearing age or those who are breastfeeding should use caution when administering INCURIN® Tablets. Wash your hands with soap and water after administration to avoid exposure to the drug. Many Prescription Medications Which of the following intravenous diuretics is the most appropriate treatment for life-threatening pulmonary edema caused by CHF? The link you have selected will take you to a third-party website. Dosage may be rounded to the nearest 12.5 mg (1/4 tablet) for practical dosing. 1. Treated dogs are susceptible to bone marrow suppression from estrogen, typified by early thrombocytopenia and potentially fatal aplastic anemia. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. In order for this medication to be effective, it must be administered as directed by the veterinarian; missed doses will negate its effect. Patients may achieve an adequate clinical response with a lower dose. Estradiol-17β concentrations decrease after ovariohysterectomy in bitches, resulting in deterioration of urethral closure within 3–6 mo. 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